2022 MLB odds, picks, bets for Friday, Sept. 23 from proven model: This four-way parlay pays well over 8-1


Future Hall of Famer Albert Pujols resumes his quest for career home run No. 700 when he and the St. Louis Cardinals (88-63) face the Los Angeles Dodgers (104-46) on Friday at Dodger Stadium. The 42-year-old Pujols, who plans to retire after this season, has 698 career home runs, which ranks fourth all-time. Only Barry Bonds (762), Hank Aaron (755) and Babe Ruth (714) have more. Los Angeles is a -170 favorite in the latest Dodgers vs. Cardinals odds from Caesars Sportsbook, while St. Louis is a +143 underdog. The over/under for runs scored is 8.

First pitch is set for 10:10 p.m. ET from Los Angeles. The game is one of 15 on the MLB schedule for Friday. Elsewhere in the majors, Yankees slugger Aaron Judge resumes his pursuit of both the American League single-season home run record and the Triple Crown when he and the Yankees take on the rival Red Sox, and the Rays and Blue Jays collide in Tampa, Fla. Before making any MLB picks or parlays, be sure to see the predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times, and it is 321-272 on top-rated MLB money-line picks since the start of the 2021 season, returning more than $600 for $100 bettors during that span. This is the same model that pegged the 2021 Atlanta Braves at 10-1 as one of three best bets to win it all last season. Anybody who has followed it has seen profitable returns.

Now, the model has locked in four confident MLB best bets for Friday. They all involve games at 7:05 p.m. ET or later, so there’s still time to get these MLB picks in. If you successfully parlay the picks, you’d be looking at a payout of well over 8-1. You can only see the model’s MLB picks at SportsLine. 

Top MLB picks today

The model, which ran 10,000 simulations on each of Friday’s games, likes Tampa Bay (-145) to knock off Toronto. The Rays (83-67) own the edge in starting pitching entering Friday. Tampa Bay starter Jeffrey Springs (9-4, 2.45 ERA) is 3-0 with a 0.89 ERA in September, which includes six scoreless innings in a 4-1 win over the Blue Jays 10 days ago.

Meanwhile, Toronto (84-66) sends out 27-year-old righty Mitch White (1-6, 5.05). Acquired in a trade from the Dodgers in August, White has struggled over the last month, going 0-3 and giving up 21 runs over 18 innings (10.50 ERA). The Blue Jays are 2-4 in games he has started, and White has not earned a victory since May 17. See who else to back right here.

Featured Game | Tampa Bay Rays vs. Toronto Blue Jays

How to make MLB picks and parlays for Friday

The model also locked in three other best bets for Friday, including a play on a big NL underdog. You can see the model’s MLB Friday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of well over 8-1? And what underdog does the model like on Friday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 321-272 run on top-rated MLB money-line picks since the start of 2021.

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